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Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration

Received: 22 May 2016     Published: 23 May 2016
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Abstract

Advancements in neurosurgical research have been central to understanding the underlying process of neural growth and regeneration (neurogenesis) and its application in the treatment and management of neurological pathologies. Recent work has shown the adult brain and central nervous system (CNS) to contain neuronal progenitors, precursor molecules as well as stem cells which play key roles in the new generation of neurones, astrocytes and oligodendrocytes. Whilst also challenging the previous dogma that no new neurones are born into the adult mammalian CNS and brain; this paper draws upon and presents an up-to-date picture of currently used “in vitro” and “in vivo” models for the study of novel techniques concerning the integration of neurones into existing neural circuitry. Breakthrough studies in Axonal Regeneration; The Application of Growth Factors; Stem cell grafting and proliferation; Synthetic materials technology; are just a few examples of key areas which have gained extensive interest, to ensure the successful clinical application of neurogenesis in various neurological pathologies. Challenges in the field are also addressed, where a future outlook to improve these novel techniques and potential areas of expandable research is also indicated.

Published in Journal of Surgery (Volume 4, Issue 2)
DOI 10.11648/j.js.20160402.20
Page(s) 49-59
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Biosynthetic Materials, Neural Growth, Neural Regeneration, Neurogenesis, Neurosurgery, Neurosurgical Research, Surgery, Surgical Research

References
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Cite This Article
  • APA Style

    Komal Sharma. (2016). Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration. Journal of Surgery, 4(2), 49-59. https://doi.org/10.11648/j.js.20160402.20

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    ACS Style

    Komal Sharma. Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration. J. Surg. 2016, 4(2), 49-59. doi: 10.11648/j.js.20160402.20

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    AMA Style

    Komal Sharma. Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration. J Surg. 2016;4(2):49-59. doi: 10.11648/j.js.20160402.20

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  • @article{10.11648/j.js.20160402.20,
      author = {Komal Sharma},
      title = {Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration},
      journal = {Journal of Surgery},
      volume = {4},
      number = {2},
      pages = {49-59},
      doi = {10.11648/j.js.20160402.20},
      url = {https://doi.org/10.11648/j.js.20160402.20},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20160402.20},
      abstract = {Advancements in neurosurgical research have been central to understanding the underlying process of neural growth and regeneration (neurogenesis) and its application in the treatment and management of neurological pathologies. Recent work has shown the adult brain and central nervous system (CNS) to contain neuronal progenitors, precursor molecules as well as stem cells which play key roles in the new generation of neurones, astrocytes and oligodendrocytes. Whilst also challenging the previous dogma that no new neurones are born into the adult mammalian CNS and brain; this paper draws upon and presents an up-to-date picture of currently used “in vitro” and  “in vivo”  models for the study of novel techniques concerning the integration of neurones into existing neural circuitry. Breakthrough studies in Axonal Regeneration; The Application of Growth Factors; Stem cell grafting and proliferation; Synthetic materials technology;  are just a few examples of key areas which have gained extensive interest, to ensure the successful clinical application of neurogenesis in various neurological pathologies. Challenges in the field are also addressed, where a future outlook to improve these novel techniques and potential areas of expandable research is also indicated.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration
    AU  - Komal Sharma
    Y1  - 2016/05/23
    PY  - 2016
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    JF  - Journal of Surgery
    JO  - Journal of Surgery
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    EP  - 59
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    AB  - Advancements in neurosurgical research have been central to understanding the underlying process of neural growth and regeneration (neurogenesis) and its application in the treatment and management of neurological pathologies. Recent work has shown the adult brain and central nervous system (CNS) to contain neuronal progenitors, precursor molecules as well as stem cells which play key roles in the new generation of neurones, astrocytes and oligodendrocytes. Whilst also challenging the previous dogma that no new neurones are born into the adult mammalian CNS and brain; this paper draws upon and presents an up-to-date picture of currently used “in vitro” and  “in vivo”  models for the study of novel techniques concerning the integration of neurones into existing neural circuitry. Breakthrough studies in Axonal Regeneration; The Application of Growth Factors; Stem cell grafting and proliferation; Synthetic materials technology;  are just a few examples of key areas which have gained extensive interest, to ensure the successful clinical application of neurogenesis in various neurological pathologies. Challenges in the field are also addressed, where a future outlook to improve these novel techniques and potential areas of expandable research is also indicated.
    VL  - 4
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Author Information
  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

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